Li S Y, Teh B S, Seow W K, Li F, Thong Y H
Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
Cancer Lett. 1990 Sep;53(2-3):175-81. doi: 10.1016/0304-3835(90)90211-f.
The novel plant flavonoid 3,5,7,-trihydroxy-4'-methoxyl-8'-prenylflavone-3-O-alpha-L-rham nopranoxide (designated baohuoside-1) was shown to have cytotoxic and cytostatic effects on 6 cancer cell-lines, by means of microscopy, 51Cr-release and growth inhibition. The IC50 on the cells tested ranged from 2.8 to 7.5 micrograms/ml. At tumouricidal concentrations, inhibition of DNA and RNA synthesis, but not protein synthesis was observed.
新型植物类黄酮3,5,7 - 三羟基 - 4'- 甲氧基 - 8'- 异戊烯基黄酮 - 3 - O - α - L - 鼠李糖苷（命名为宝藿苷 - 1）通过显微镜检查、51Cr释放试验和生长抑制试验，显示对6种癌细胞系具有细胞毒性和细胞生长抑制作用。在所测试的细胞上，其半数抑制浓度（IC50）范围为2.8至7.5微克/毫升。在杀肿瘤浓度下，观察到DNA和RNA合成受到抑制，但蛋白质合成未受影响。
