Department of Ophthalmology, University of South Florida, Tampa, FL, USA.
Retina. 2012 Apr;32(4):754-9. doi: 10.1097/IAE.0b013e3182252a92.
To determine if patients with macular hole report an increased family history of macular hole compared with control patients and compare the report of family history between patients with unilateral and bilateral macular holes.
This was a multicenter case-control study. Charts of patients coded with diagnosis of macular hole were reviewed, and the diagnosis of idiopathic full-thickness macular hole was ascertained in 166 patients. The control group comprised 136 patients without macular hole or trauma who presented with senile cataract. Family history was obtained from all patients through a telephone interview.
Six of 166 (3.6%) macular hole patients surveyed reported a history of macular hole in a primary relative compared with none of 136 (0.0%) control patients (odds ratio is infinity, with 95% confidence interval 1.295 to infinity); however, this finding may be explained by confounders such as age and number of family members. Two of the 142 (1.4%) patients with unilateral holes versus 4 of the 24 (16.7%) patients with bilateral holes reported a family history (odds ratio is 0.0714, with 95% confidence interval 0.0063 to 0.5537), and this finding remains significant when logistic regression is performed to evaluate variables of age and number of family members as potential confounders.
There is an increased report of familial occurrence of macular hole in patients with macular holes compared with control patients; however, logistic regression relates this finding to variables of age and number of family members. Patients with bilateral macular holes are more likely to report a family history of macular hole than patients with unilateral macular holes, and this finding remains significant in the presence of age and number of family members. These findings may suggest a familial component to macular hole.
确定与对照患者相比，患有黄斑裂孔的患者是否报告家族中有更多的黄斑裂孔病史，并比较单侧和双侧黄斑裂孔患者的家族史报告。
这是一项多中心病例对照研究。对编码为黄斑裂孔诊断的患者图表进行了回顾，在 166 名患者中确定了特发性全层黄斑裂孔的诊断。对照组由 136 名无黄斑裂孔或外伤且患有老年性白内障的患者组成。通过电话访谈从所有患者处获得家族史。
在接受调查的 166 名黄斑裂孔患者中，有 6 名（3.6％）报告了一级亲属中有黄斑裂孔病史，而在 136 名对照患者中无一人（0.0％）（比值比为无穷大，95％置信区间为 1.295 至无穷大）；但是，这种发现可能是由于年龄和家庭成员数量等混杂因素引起的。在 142 名单侧孔患者中有 2 名（1.4％），在 24 名双侧孔患者中有 4 名（16.7％）报告了家族史（比值比为 0.0714，95％置信区间为 0.0063 至 0.5537），当进行逻辑回归以评估年龄和家庭成员数量等潜在混杂因素的变量时，这一发现仍然具有统计学意义。
与对照患者相比，黄斑裂孔患者报告黄斑裂孔家族史的比例增加；但是，逻辑回归将这种发现与年龄和家庭成员数量等变量联系起来。与单侧黄斑裂孔患者相比，双侧黄斑裂孔患者更有可能报告黄斑裂孔家族史，而且在存在年龄和家庭成员数量的情况下，这一发现仍然具有统计学意义。这些发现可能表明黄斑裂孔存在家族因素。
