Niwa Hideyasu, Terasaki Hiroko, Ito Yasuki, Miyake Yozo
Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
Am J Ophthalmol. 2005 Sep;140(3):370-5. doi: 10.1016/j.ajo.2005.03.070.
To determine the incidence of developing an idiopathic full-thickness macular hole in fellow eyes that have vitreofoveal attachments and perifoveal vitreous detachment in patients with unilateral idiopathic macular hole.
Retrospective cross-sectional observational study.
The fellow eyes of 201 patients with full-thickness macular holes were examined by optical coherence tomography (OCT). A subset of 58 fellow eyes with vitreofoveal attachments and perifoveal vitreous detachment was observed during follow-up, and the changes in the vitreofoveal attachment within 24 months from the initial OCT examination were investigated.
In the 58 eyes, the vitreofoveal relationship changed in 27 eyes. Among the 27 eyes, three eyes developed a full-thickness macular hole, and the other 24 eyes developed a posterior vitreous detachment only over the fovea or a complete posterior vitreous detachment without macular hole formation. The vitreofoveal relationship did not change in 31 eyes during the 24-month period.
From an analysis of the changes in the vitreoretinal relationship identified by OCT, three (11%) of 27 fellow eyes in patients with unilateral idiopathic macular hole developed a full-thickness macular hole.
确定单侧特发性黄斑裂孔患者中，对侧眼存在玻璃体黄斑附着和黄斑区周边玻璃体脱离时，发生特发性全层黄斑裂孔的发生率。
回顾性横断面观察研究。
采用光学相干断层扫描（OCT）检查201例全层黄斑裂孔患者的对侧眼。对其中58例存在玻璃体黄斑附着和黄斑区周边玻璃体脱离的对侧眼进行随访观察，研究自初次OCT检查起24个月内玻璃体黄斑附着情况的变化。
在这58只眼中，27只眼的玻璃体黄斑关系发生了改变。在这27只眼中，3只眼发展为全层黄斑裂孔，另外24只眼仅在黄斑区出现玻璃体后脱离或完全性玻璃体后脱离但未形成黄斑裂孔。在24个月期间，31只眼的玻璃体黄斑关系未发生改变。
通过对OCT所确定的玻璃体视网膜关系变化进行分析，单侧特发性黄斑裂孔患者的27例对侧眼中，有3例（11%）发展为全层黄斑裂孔。
