[几种进行性肌营养不良症的发病机制]
[Pathogenesis of several forms of progressive muscular dystrophy].
作者信息
Lobzin V S, Shapkin V I, Kozlov A V
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(3):267-72.
PMID:220822
Abstract
The level of cyclic 3,5-adenosine monophosphate (cAMP), the activity of adenylate cyclase (AC) and phosphodiesterase (PDE) were studied in bioptates of the muscles of 17 patients with different forms of myopathy. The cAMP level and AC activity were decreased while that of PDE was increased. These changes are particularly demonstrative in patients with Erba type of myopathy. It is recommended that beta-adrenomimetic drugs and PDE inhibitors may be tried in pathogenetic therapy.
摘要
研究了17例不同类型肌病患者肌肉活检组织中环磷酸腺苷（cAMP）水平、腺苷酸环化酶（AC）和磷酸二酯酶（PDE）的活性。结果显示，cAMP水平和AC活性降低，而PDE活性升高。这些变化在埃尔巴型肌病患者中尤为明显。建议在病因治疗中尝试使用β-肾上腺素能激动剂和PDE抑制剂。
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