Král J, Spácil J, Hradec J, Cech E
III. interní katedra 1. lékarské fakulty Univerzity Karlovy, Praha.
Cas Lek Cesk. 1990 Aug 17;129(33):1029-32.
In a prospective study the authors investigated 30 pregnant women (mean age 27 +/- 5.5 years) with prolapse of the mitral valve confirmed on echocardiography, without significant mitral regurgitation, in order to assess whether mitral valve prolapse is a risk factor for the development of complications during gestation and childbirth. As control served a group of 30 healthy pregnant women of corresponding age and number of previous pregnancies, incidence of complications during pregnancy, the type of delivery, sex, length, weight and maturity of the neonates. In women with mitral valve prolapse the authors recorded a significantly higher incidence of subjective complaints such as palpitations associated in 7 of 8 cases with sinus tachycardia 110-140/min. at rest and with vasovagal syncopes. The palpitations were always favourably influenced by beta-blocker therapy or by calcium antagonists. Mitral valve prolapse without haemodynamically significant mitral regurgitation during pregnancy is not a significant risk factor for the development of complications.
在一项前瞻性研究中，作者调查了30名经超声心动图确诊为二尖瓣脱垂且无明显二尖瓣反流的孕妇（平均年龄27±5.5岁），以评估二尖瓣脱垂是否为妊娠期和分娩期发生并发症的危险因素。对照组为30名年龄和既往妊娠次数相当的健康孕妇，记录了妊娠期间并发症的发生率、分娩方式、新生儿的性别、身长、体重和成熟度。在二尖瓣脱垂的女性中，作者记录到主观症状的发生率显著更高，如心悸，8例中有7例与静息时心率为110 - 140次/分钟的窦性心动过速以及血管迷走性晕厥有关。心悸总是能通过β受体阻滞剂治疗或钙拮抗剂得到有效缓解。孕期无血流动力学显著意义的二尖瓣反流的二尖瓣脱垂并非发生并发症的显著危险因素。
