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一个摩洛哥犹太家庭的八个兄弟姐妹中出现多种垂体激素缺乏症。

Multiple pituitary hormone deficiencies in eight siblings of one Jewish Moroccan family.

作者信息

Adler-Bier M, Pertzeland A, Laron Z, Lieberman E, Moses S

出版信息

Acta Paediatr Scand. 1979 May;68(3):401-4. doi: 10.1111/j.1651-2227.1979.tb05027.x.

Abstract

In a Jewish Moroccan inbred family, 8 of 12 siblings were found to have multiple deficiencies of pituitary hormones, including GH, TSH and gonadotrophins. The parents showed no deficiency and are in good health, as are the other 4 siblings. The investigations carried out indicate that in this family the etiology is hereditary in nature, probably being autosomal recessive, with the defect located in the pituitary gland.

摘要

在一个摩洛哥犹太裔近亲家庭中,12个兄弟姐妹中有8人被发现存在多种垂体激素缺乏,包括生长激素、促甲状腺激素和促性腺激素。父母没有激素缺乏症状,身体健康,其他4个兄弟姐妹也是如此。所进行的调查表明,在这个家庭中,病因本质上是遗传性的,可能是常染色体隐性遗传,缺陷位于垂体。

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