Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Org Lett. 2011 Dec 16;13(24):6436-9. doi: 10.1021/ol202728v. Epub 2011 Nov 15.
A gram-scale enantiospecific synthesis of the A'B'-subunit of angelmicin B is reported. The synthesis involves a Lewis acid catalyzed contrasteric Diels-Alder reaction and a tandem silyl zincate 1,6-addition/enolate oxidation sequence.
报告了一种克级规模的手性 angelmicin B A'B'-亚单位的对映选择性合成方法。该合成涉及路易斯酸催化的对映选择性 Diels-Alder 反应和串联硅锌试剂 1,6-加成/烯醇化物氧化序列。