钯催化的异氰化物插入合成 4-氨基酞嗪-1(2H)-酮。
Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion.
机构信息
Department of Chemistry & Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
出版信息
Org Lett. 2011 Dec 16;13(24):6496-9. doi: 10.1021/ol202784d. Epub 2011 Nov 15.
PMID:22085248
Abstract
Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.
摘要
钯催化的广泛取代的邻-(拟)卤代苯甲酸酯和肼与异氰化物插入反应，随后进行内酰胺化，有效地得到了难以通过经典方法区域选择性获得的 4-氨基酞嗪-1(2H)-酮。
Zotero 插件