金催化的通过酰氧基迁移/炔基酯的分子内[3 + 2]环加成的哌啶合成。

Au-catalyzed piperidine synthesis via tandem acyloxy migration/intramolecular [3 + 2] cycloaddition of enynyl esters.

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Gansu 730000, People's Republic of China.

出版信息

Org Lett. 2011 Dec 16;13(24):6448-51. doi: 10.1021/ol202746s. Epub 2011 Nov 15.

DOI:10.1021/ol202746s

PMID:22085340

Abstract

An Au-catalyzed tandem protocol involving enynyl ester isomerization and subsequent intramolecular [3 + 2] cyclization has been developed. This strategy provides an efficient approach for the synthesis of polyfunctional piperidines, which are subunits of many bioactive molecules.

摘要

Au 催化的串联反应涉及烯基酯异构化和随后的分子内[3+2]环化，已被开发出来。该策略为合成多官能团哌啶提供了一种有效的方法，哌啶是许多生物活性分子的亚单位。