更年期困扰的顺势疗法管理。

Central Council for Research in Homoeopathy (CCRH), New Delhi, India.

J Altern Complement Med. 2011 Nov;17(11):1037-42. doi: 10.1089/acm.2010.0301.

OBJECTIVES

The purpose of this study was to ascertain the usefulness of homeopathic therapy in the management of distressing symptoms encountered during climacteric years in women (primary objective) and also the changes brought about in the levels of follicle-stimulating hormone (FSH) and lipid profile in these women after homeopathic treatment (secondary objective).

MATERIALS AND METHODS

An open, multicenter, prospective, observational study was carried out to ascertain the usefulness of homeopathic treatment in distress during climacteric years (DDCY). Patients were enrolled from the general outpatient department of the six Institutes/Units of Central Council for Research in Homoeopathy (CCRH) and were required to complete a follow-up period of 1 year as per the protocol designed by the CCRH. A uniform questionnaire assessing 15 predefined symptoms of menopause was adopted, with assessment of each symptom at every visit. Levels of serum FSH and lipid profile were monitored at entry and at completion. Effect size of the study was also calculated. CARA Software was used for repertorization of the presenting symptoms of menopause along with the characteristic attributes of each patient to arrive at a simillimum. The selected medicine was prescribed in a single dose as per the homeopathic principles. The assessment of the results was made through statistical analysis using the Wilcoxon signed rank test on Statistical Package for Social Sciences (SPSS) comparing symptom score at entry and completion of 1 year of treatment and t test for analyzing improvement in laboratory findings.

RESULTS

Homeopathic therapy was found to be useful in relieving menopausal distressing symptoms such as hot flashes, night sweats, anxiety, palpitation, depression, insomnia, and so on. Influence on serum levels of FSH, high-density lipoprotein, and low-density lipoprotein was not significant but serum levels of cholesterol, triglycerides, and very-low-density lipoprotein decreased significantly. Effect size of the study was found to be large. The medicines found to be most frequently indicated and useful were Sepia, Lachesis, Calcarea carb., Lycopodium, and Sulphur.

CONCLUSIONS

This study proves the usefulness of homeopathic medicines in relieving DDCY.

目的

本研究旨在确定顺势疗法在管理女性更年期困扰症状方面的有效性（主要目标），并确定这些女性在接受顺势疗法治疗后卵泡刺激素（FSH）水平和血脂谱的变化（次要目标）。

材料和方法

进行了一项开放、多中心、前瞻性、观察性研究，以确定顺势疗法在更年期困扰（DDCY）中的治疗效果。患者从中央顺势疗法研究理事会（CCRH）的六个研究所/单位的普通门诊招募，并按照 CCRH 设计的方案完成 1 年的随访期。采用了一份评估 15 项绝经前预设症状的统一问卷，每次就诊时评估每个症状。在入组时和完成时监测血清 FSH 水平和血脂谱。还计算了研究的效应量。采用 CARA 软件对绝经的表现症状以及每位患者的特征属性进行归宗，以确定类似物。根据顺势疗法原则，以单一剂量开出所选药物。使用社会科学统计软件包（SPSS）的 Wilcoxon 符号秩检验对结果进行评估，比较治疗 1 年后的症状评分和 1 年随访结束时的症状评分，并使用 t 检验分析实验室结果的改善情况。

结果

顺势疗法被发现可有效缓解更年期困扰症状，如潮热、盗汗、焦虑、心悸、抑郁、失眠等。对血清 FSH、高密度脂蛋白和低密度脂蛋白水平的影响不显著，但胆固醇、甘油三酯和极低密度脂蛋白水平显著降低。研究的效应量较大。发现最常被指示和有效的药物是 Sepia、Lachesis、Calcarea carb.、Lycopodium 和 Sulphur。