SLCO1B1 1b 与日本低剂量阿司匹林使用者消化性溃疡的相关性。
Association of SLCO1B1 1b with peptic ulcer amongst Japanese patients taking low-dose aspirin.
机构信息
Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.
出版信息
Dig Liver Dis. 2012 Mar;44(3):201-5. doi: 10.1016/j.dld.2011.10.005. Epub 2011 Nov 15.
BACKGROUND
In the recent case-control study, we showed an inverse association between peptic ulcer and angiotensin type 1 receptor (AT1R) blockers (ARBs) or HMG-Co A reductase inhibitors (statins). The aim was to evaluate whether the genotypes of uptake and efflux transporters of ARBs and statins relate to the presence of peptic ulcer and/or ulcer bleeding associated with aspirin use.
METHODS
Patients taking 100mg of enteric-coated aspirin for cardiovascular diseases who also participated in endoscopic surveillance were studied. SLCO1B, ABCC2, ABCG2, and MDR1 genotypes were determined by PCR or PCR-RFLP.
RESULTS
492 patients enrolled including 78 with peptic ulcer. The frequencies of the SLCO1B1 521TT genotype were significantly higher in the ulcer group (p=0.006) compared to the controls. After adjustment for significant factors, the SLCO1B1 1b haplotype was significantly associated with peptic ulcer (OR, 3.64; 95% CI, 1.81-7.29).
CONCLUSIONS
SLCO1B1 1b haplotype may identify patients at increased risk for aspirin-induced peptic ulcer.
背景
在最近的病例对照研究中，我们发现消化性溃疡与血管紧张素 1 型受体（AT1R）阻滞剂（ARB）或 HMG-CoA 还原酶抑制剂（他汀类药物）呈负相关。目的是评估 ARB 和他汀类药物摄取和外排转运体的基因型是否与阿司匹林相关的消化性溃疡和/或溃疡出血的存在有关。
方法
研究了正在服用 100mg 肠溶阿司匹林进行心血管疾病治疗且同时参加内镜监测的患者。通过 PCR 或 PCR-RFLP 确定 SLCO1B1、ABCC2、ABCG2 和 MDR1 基因型。
结果
共纳入 492 例患者，其中 78 例患有消化性溃疡。与对照组相比，溃疡组中 SLCO1B1 521TT 基因型的频率明显更高（p=0.006）。在调整了显著因素后，SLCO1B1 1b 单倍型与消化性溃疡显著相关（OR，3.64；95% CI，1.81-7.29）。
结论
SLCO1B1 1b 单倍型可能可以识别出阿司匹林引起的消化性溃疡风险增加的患者。
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