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The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy.阿司匹林所致消化性溃疡的预防因素：阿司匹林溃疡与胃体萎缩。
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血型、环氧化酶-1（COX-1）基因启动子功能多态性（T-1676C）及临床因素对低剂量阿司匹林心血管预防期间消化性溃疡发生的影响。

Impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.

作者信息

Wang Pin-Yao, Chen Hsiu-Ping, Chen Angela, Tsay Feng-Woei, Lai Kwok-Hung, Kao Sung-Shuo, Chen Wen-Chi, Kuo Chao-Hung, Peng Nan-Jing, Tseng Hui-Hwa, Hsu Ping-I

机构信息

Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.

出版信息

Biomed Res Int. 2014;2014:616018. doi: 10.1155/2014/616018. Epub 2014 Aug 27.

DOI:10.1155/2014/616018
PMID:25243161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4163467/
Abstract

AIMS

To investigate the impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter, and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.

METHODS

In a case-control study including 111 low-dose aspirin users with peptic ulcers and 109 controls (asymptomatic aspirin users), the polymorphism (T-1676C) of the COX-1 gene promoter was genotyped, and blood type, H pylori status, and clinical factors were assessed.

RESULTS

Univariate analysis showed no significant differences in genotype frequencies of the COX-1 gene at position -1676 between the peptic ulcer group and control group. Multivariate analysis revealed that blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID were the independent risk factors for the development of peptic ulcer with the odds ratios of the 2.1, 3.1, 27.6, and 2.9, respectively.

CONCLUSION

The C-1676T polymorphism in the COX-1 gene promoter is not a risk factor for ulcer formation during treatment with low-dose aspirin. Blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID are of independent significance in predicting peptic ulcer development during treatment with low-dose aspirin.

摘要

目的

探讨血型、COX-1基因启动子功能多态性（T-1676C）及临床因素对低剂量阿司匹林心血管预防期间消化性溃疡发生的影响。

方法

在一项病例对照研究中，纳入111名患有消化性溃疡的低剂量阿司匹林使用者和109名对照者（无症状阿司匹林使用者），对COX-1基因启动子的多态性（T-1676C）进行基因分型，并评估血型、幽门螺杆菌状态和临床因素。

结果

单因素分析显示，消化性溃疡组和对照组在-1676位点的COX-1基因基因型频率无显著差异。多因素分析显示，O型血、高龄、消化性溃疡病史和同时使用非甾体抗炎药是消化性溃疡发生的独立危险因素，比值比分别为2.1、3.1、27.6和2.9。

结论

COX-1基因启动子中的C-1676T多态性不是低剂量阿司匹林治疗期间溃疡形成的危险因素。O型血、高龄、消化性溃疡病史和同时使用非甾体抗炎药在预测低剂量阿司匹林治疗期间消化性溃疡的发生方面具有独立意义。