纳曲酮的研发：一种新型麻醉拮抗剂。
Research and development of naltrexone: a new narcotic antagonist.
作者信息
Julius D A
出版信息
Am J Psychiatry. 1979 Jun;136(6):782-6. doi: 10.1176/ajp.136.6.782.
The author reviews the history of federally supported research in the field of narcotic antagonist therapy, focusing on social, political, and governmental issues. He describes the criteria for establishing an optimum narcotic antagonist, the legal guidelines for drug development, and the currently available narcotic antagonists. Research supported by the National Institute on Drug Abuse has indicated that naltrexone is the most promising drug in this category. The author discusses the safety and clinic use of naltrexone, the status of the NIDA naltrexone program, and plans for future development of the drug.
作者回顾了联邦政府支持的麻醉拮抗剂治疗领域的研究历史，重点关注社会、政治和政府问题。他描述了确定最佳麻醉拮抗剂的标准、药物开发的法律准则以及目前可用的麻醉拮抗剂。美国国家药物滥用研究所支持的研究表明，纳曲酮是该类别中最有前景的药物。作者讨论了纳曲酮的安全性和临床应用、美国国家药物滥用研究所纳曲酮项目的现状以及该药物未来的开发计划。
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