Vinh Donald C, Bin Dhuban Khalid, Mason Helen, Lejtenyi Duncan, Jung Sungmi, Sheppard Donald C, Faury Damien, Jabado Nada, Piccirillo Ciriaco A
Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.
Clin Vaccine Immunol. 2012 Jan;19(1):109-12. doi: 10.1128/CVI.05456-11. Epub 2011 Nov 16.
Graft-versus-host disease is uncommon in autologous hematopoietic cell transplantation (HCT) and is typically brief and mild. We report unusual, protracted, and severe Omenn syndrome-like autoaggression following autologous HCT. We identified a profound FOXP3(+) regulatory T cell defect that coincided with hyperinflammatory T cell responses which were reversible with rapamycin in vitro.
移植物抗宿主病在自体造血细胞移植（HCT）中并不常见，通常病程短暂且症状轻微。我们报告了自体HCT后出现的罕见、迁延且严重的类奥门综合征自身攻击情况。我们发现了一种严重的FOXP3(+)调节性T细胞缺陷，这与高炎症性T细胞反应同时出现，而雷帕霉素在体外可使这些反应逆转。
