School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK.
Psychopharmacology (Berl). 2012 Jan;219(2):253-70. doi: 10.1007/s00213-011-2560-5. Epub 2011 Nov 18.
Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented.
This study aims to summarise the main results of the 5CSRTT in mice, with special focus on impulsivity.
The 5CSRTT can be used to explore aspects of both attentional and inhibitory control mechanisms.
Different manipulations of the task parameters can lead to different results; adjusting the protocol as a function of the main variable of interest or the standardisation of the protocol to be applied to a large set of strains will be desirable.
The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice.
老鼠是研究注意力和冲动性相关的遗传和环境因素的有用工具。五选择连续反应时任务（5CSRTT）范式在大鼠中得到了很好的建立，但它在小鼠中的可转移性记录较少。
本研究旨在总结 5CSRTT 在小鼠中的主要结果，特别关注冲动性。
5CSRTT 可用于探索注意力和抑制控制机制的各个方面。
任务参数的不同操作会导致不同的结果；根据主要感兴趣的变量调整方案或使方案标准化以应用于大量品系将是可取的。
5CSRTT 已被证明是研究小鼠冲动性的有用工具。
