强烈推荐在 T1b 期胆囊癌中进行区域淋巴结清扫。
Regional lymphadenectomy strongly recommended in T1b gallbladder cancer.
出版信息
World J Gastroenterol. 2011 Oct 14;17(38):4347-8. doi: 10.3748/wjg.v17.i38.4347.
Abstract
This article discusses the adequate treatment of early gallbladder cancer (T1a, T1b) and is based on published studies extending over nearly 3 decades. Randomized studies and meta analyses comparing different surgical treatments do not exist. The literature shows that in up to 20% of patients lymph node metastasis are found in T1b gallbladder cancer. Due to high malignancy with early angiolymphatic spread and resistance to chemotherapy and radiation on the one hand, and the relative low operative risk of extended cholecystectomy (cholecystectomy and regional lymphadenectomy) on the other hand, we believe that this procedure is mandatory in early gallbladder cancer.
摘要
本文讨论了早期胆囊癌（T1a、T1b）的充分治疗，所依据的是近 30 年来发表的研究。目前不存在比较不同手术治疗方法的随机研究和荟萃分析。文献表明，多达 20%的 T1b 胆囊癌患者存在淋巴结转移。由于一方面恶性程度高，具有早期血管淋巴管扩散和对化疗和放疗的耐药性，另一方面广泛胆囊切除术（胆囊切除术和区域淋巴结清扫术）的手术风险相对较低，我们认为在早期胆囊癌中必须进行这种手术。
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本文引用的文献
1
Systematic review on the surgical treatment for T1 gallbladder cancer.关于 T1 期胆囊癌的外科治疗的系统评价。
World J Gastroenterol. 2011 Jan 14;17(2):174-80. doi: 10.3748/wjg.v17.i2.174.
2
Precise preoperative imaging and adequate oncologic resection is most important in achieving long-term prognosis in gallbladder cancer.精确的术前影像学检查和充分的肿瘤切除对于实现胆囊癌的长期预后至关重要。
World J Surg. 2010 Sep;34(9):2262-3; author reply 2264-5. doi: 10.1007/s00268-010-0508-2.
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Role of regional lymphadenectomy in different stage of gallbladder carcinoma.区域淋巴结清扫术在胆囊癌不同分期中的作用。
Hepatogastroenterology. 2009 May-Jun;56(91-92):593-6.
4
What is an adequate extent of resection for T1 gallbladder cancers?T1期胆囊癌的充分切除范围是多少？
Ann Surg. 2008 May;247(5):835-8. doi: 10.1097/SLA.0b013e3181675842.
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