Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.
Dermatol Surg. 2012 Mar;38(3):430-6. doi: 10.1111/j.1524-4725.2011.02213.x. Epub 2011 Nov 7.
Intense pulsed light (IPL) is widely used in treating skin conditions and has been reported to increase collagen and elastic fibers without damaging the epidermis.
To evaluate the effect of variation in the number of passes and intervals of IPL treatments on photorejuvenation in rats.
Groups of two rats each were exposed to two or four passes of an IPL source using a fluence of 30 J/cm(2) and a cut-off filter of 560 nm at 1- or 3-week intervals. The collagen and elastic fiber content in stained tissue biopsies and the thickness of the collagen fibers of IPL-irradiated and unexposed skin regions were compared.
Collagen distribution and collagen fiber diameter was in IPL-irradiated than in control regions. The number of passes did not significantly affect the collagen fiber thickness, but the collagen fibers from the 3-week-interval groups were thicker than those of the 1-week-interval groups (p < .001).
IPL increased dermal collagen fibers and collagen fiber diameter, suggesting efficacy in photorejuvenation and wrinkle reduction.
强脉冲光（IPL）广泛用于治疗皮肤疾病，已被报道可增加胶原蛋白和弹性纤维，而不会损伤表皮。
评估 IPL 治疗次数和间隔时间的变化对大鼠光老化的影响。
每组两只大鼠，使用 30 J/cm(2)的能量和 560nm 的截止滤波器，分别接受两次或四次 IPL 照射。比较染色组织活检中的胶原蛋白和弹性纤维含量以及 IPL 照射和未照射皮肤区域的胶原纤维厚度。
与对照组相比，IPL 照射区域的胶原蛋白分布和胶原纤维直径更大。治疗次数对胶原纤维厚度没有显著影响，但 3 周间隔组的胶原纤维比 1 周间隔组更厚（p < 0.001）。
IPL 增加了真皮胶原纤维和胶原纤维直径，提示其在光老化和皱纹减少方面具有疗效。
