Dermatologic Surgery, University of Toronto, Toronto, Ontario, Canada.
Dermatol Surg. 2012 Jan;38(1):58-67. doi: 10.1111/j.1524-4725.2011.02148.x. Epub 2011 Sep 7.
High-intensity focused ultrasound (HIFU) is a nonsurgical, noninvasive body sculpting method.
To investigate preferences for treatment settings using a HIFU device.
HIFU was applied to the anterior abdomen in three passes of decreasing depth (1.6, 1.3, and 1.1 cm) in patients randomized to HIFU energy levels (each of 3 passes [total]) of 47 (141), 52 (156), or 59 (177) J/cm(2). The primary assessment was week 12 post-treatment change from baseline waist circumference at the level of the iliac crest for all treatment groups combined.
The primary assessment achieved statistical significance (least squares mean 2.51 cm, 95% confidence interval [CI] = -3.14 to -1.88; p < .001), with no significant differences between groups. At week 12, 69% to 86% of patients and 73% to 79% of investigators rated appearance as improved or much improved. The average worst pain (100-mm visual analog scale) experienced during treatment was mild (47 J/cm(2): 17.1 mm, 95% CI = 4.33-29.81 mm; 52 J/cm(2): 24.6 mm, 95% CI = 12.24-36.95 mm; 59 J/cm(2): 30.9 mm, 95% CI = 18.71-43.17 mm). There were no serious adverse events.
HIFU treatment at different energy levels and multiple tissue depths was well tolerated and effective in reducing waist circumference.
高强度聚焦超声（HIFU）是一种非手术、非侵入性的身体塑形方法。
研究使用 HIFU 设备的治疗环境偏好。
将 HIFU 应用于患者的前腹部，在三个深度逐渐减小的区域（1.6、1.3 和 1.1cm）进行三次处理（每次处理三条路径[总共有 3 次处理]），能量水平分别为 47（141）、52（156）或 59（177）J/cm²。主要评估是所有治疗组联合治疗后 12 周时髂嵴水平的腰围与基线相比的变化。
主要评估达到了统计学意义（最小二乘均数 2.51cm，95%置信区间[CI] = -3.14 至-1.88；p <.001），组间无显著差异。在第 12 周时，69%至 86%的患者和 73%至 79%的研究者认为外观有所改善或明显改善。治疗过程中平均最严重疼痛（100mm 视觉模拟量表）为轻度（47J/cm²：17.1mm，95%CI = 4.33-29.81mm；52J/cm²：24.6mm，95%CI = 12.24-36.95mm；59J/cm²：30.9mm，95%CI = 18.71-43.17mm）。没有严重不良事件。
在不同能量水平和多个组织深度下进行 HIFU 治疗可耐受良好，有效减少腰围。
