Han Ting-ting, Huang Xiao-jun, Liu Kai-yan, Liu Dai-hong, Chen Huan, Han Wei, Zhang Xiao-hui, Wang Yu, Chen Yu-hong, Wang Feng-rong, Zhao Ting, Chen Yao, Xu Lan-ping
Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
Zhonghua Nei Ke Za Zhi. 2011 Aug;50(8):654-8.
To analyze the epidemiologic features of blood stream infection (BSI) during the period of agranulocytosis after hematopoietic stem cell transplantation (HSCT) in our hospital, and provide the basis for the empirical therapy.
The consecutive hematopoietic stem cell transplantation recipients conducted between January 2008 and October 2010 were studied retrospectively, to identify the current incidence, etiology for BSI and associated mortality during the period of agranulocytosis.
Totally 75 patients were diagnosed as BSI. The incidence of BSI was 9.6% (75/784) in HSCT during the period of agranulocytosis, 17.0% (75/441) in febrile patients. The pathogen testing showed that 64.4% were G(-) bacteria, 30.1% were G(+) bacterial and 5.5% were fungi. All G(-) bacteria except one were sensitive to carbapenems; all G(+) bacteria except one were sensitive to vancomycin. Among the 75 patients, 9 (12.0%) experienced septic shock and 5 (6.7%) died.
The pathogens of the BSI in the cohort are G(-) bacteria, followed by G(+) bacteria and fungi. Carbapenems and vancomycin are the first drugs for the experiential therapy.
分析我院造血干细胞移植（HSCT）后粒细胞缺乏期血流感染（BSI）的流行病学特征，为经验性治疗提供依据。
回顾性研究2008年1月至2010年10月期间连续进行造血干细胞移植的受者，以确定粒细胞缺乏期BSI的当前发病率、病因及相关死亡率。
共75例患者被诊断为BSI。粒细胞缺乏期HSCT患者中BSI的发病率为9.6%（75/784），发热患者中为17.0%（75/441）。病原菌检测显示，64.4%为革兰阴性菌，30.1%为革兰阳性菌，5.5%为真菌。除1株外，所有革兰阴性菌对碳青霉烯类敏感；除1株外，所有革兰阳性菌对万古霉素敏感。75例患者中，9例（12.0%）发生感染性休克，5例（6.7%）死亡。
该队列中BSI的病原菌以革兰阴性菌为主，其次为革兰阳性菌和真菌。碳青霉烯类和万古霉素是经验性治疗的首选药物。
