UK National Cancer Research Institute (NCRI) Adult ALL Subgroup, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
Hematol Oncol Clin North Am. 2011 Dec;25(6):1255-79, viii. doi: 10.1016/j.hoc.2011.09.008.
Approximately half of all adults with acute lymphoblastic leukemia now survive long term. This article summarizes the current approaches to treating acute lymphoblastic leukemia in adults, with a focus on a pragmatic approach to decision making. Coupled with a particularly punishing and often complex combination chemotherapy treatment regimen, treatment-related morbidity and mortality are frequent, and this article focuses on these situations. The field will change significantly over the next few years with many ongoing clinical studies and molecular insights which will be translated into providing prognostic information and novel therapeutic targets.
现在，大约有一半的急性淋巴细胞白血病成人患者能够长期生存。本文总结了目前成人急性淋巴细胞白血病的治疗方法，重点介绍了一种实用的决策方法。由于采用了特别苛刻且往往复杂的联合化疗治疗方案，治疗相关的发病率和死亡率很高，本文重点介绍了这些情况。随着许多正在进行的临床研究和分子研究的进展，这一领域在未来几年内将发生重大变化，这些研究成果将转化为提供预后信息和新的治疗靶点。
