State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
FEBS Lett. 2011 Dec 15;585(24):4002-9. doi: 10.1016/j.febslet.2011.11.008. Epub 2011 Nov 13.
Coinfection with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) accelerates hepatitis C disease progression; however, the mechanism underlying this effect is unknown. Here, we investigated the role of HIV-1 in HCV gene expression and the mechanism involved in this regulation. We discovered that HIV-1 Rev protein activates HCV gene expression. We further revealed that Rev binds to the internal loop of the HCV 5'-untranslated region (5'-UTR) to stimulate HCV IRES-mediated translation.
人类免疫缺陷病毒 1（HIV-1）和丙型肝炎病毒（HCV）的合并感染会加速丙型肝炎的疾病进展；然而，这种效应的机制尚不清楚。在这里，我们研究了 HIV-1 在 HCV 基因表达中的作用以及这种调控所涉及的机制。我们发现 HIV-1 Rev 蛋白激活 HCV 基因表达。我们进一步揭示 Rev 通过结合 HCV 5'-非翻译区（5'-UTR）的内环来刺激 HCV IRES 介导的翻译。
