Jilg W, Schmidt M, Deinhardt F
Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Universität München.
Dtsch Med Wochenschr. 1990 Oct 12;115(41):1545-8. doi: 10.1055/s-2008-1065189.
One to three repeat vaccinations were undertaken in 63 persons (32 males, 31 females; mean age 29 [17-59] years) who had not or inadequately responded to basal immunization with hepatitis B vaccine (47 non- and 16 hyporesponders). After re-vaccination, 12 of the 47 nonresponders and 11 of 16 hyporesponders formed specific antibodies against hepatitis B surface antigen, anti-HBs, at concentrations above 10 IU/l. Six of 14 persons who had not responded to the first repeat vaccination reached anti-HBs concentrations above 10 U/l after a further injection. Vaccination response was age-dependent. The median age of those subjects who responded to the first re-vaccination was 27 (19-45) years, while the non-responders' median age was 34 (22-59) years (P less than 0.05). Re-vaccination also raised initially low anti-HBs values. These results indicate that some of the nonresponders can obtain reliable protection by revaccination(s).
对63名（32名男性，31名女性；平均年龄29[17 - 59]岁）未对乙肝疫苗基础免疫产生应答或应答不足的人员进行了1至3次重复接种（47名无应答者和16名低应答者）。再次接种后，47名无应答者中的12名以及16名低应答者中的11名产生了浓度高于10 IU/l的针对乙肝表面抗原的特异性抗体，即抗-HBs。14名首次重复接种未产生应答的人员中，有6名在再次注射后抗-HBs浓度高于10 U/l。接种反应与年龄有关。首次重复接种产生应答的受试者的中位年龄为27（19 - 45）岁，而无应答者的中位年龄为34（22 - 59）岁（P<0.05）。再次接种也提高了最初较低的抗-HBs值。这些结果表明，一些无应答者可以通过再次接种获得可靠的保护。
