Department of Orthopaedics, the First Affiliated Hospital, Medical College, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
J Mol Neurosci. 2012 Jun;47(2):380-8. doi: 10.1007/s12031-011-9662-8. Epub 2011 Nov 18.
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has been found to play an essential role in cell proliferation, but whether it was involved in Schwann cells differentiation has never been studied. We have found in sciatic nerve injury that expression of PPAR-γ decreases mainly in Schwann cells, and it was also increased in differentiated Schwann cells. Further, activated PPAR-γ by the endogenous ligand 15 d-PGJ(2) increased expressions of PPAR-γ level and Schwann cell differentiation, and this effect may be protected by its antagonist GDW9662. These results indicate that PPAR-γ could promote Schwann cell differentiation, which plays an important role in peripheral nerve injury and regeneration.
过氧化物酶体增殖物激活受体-γ（PPAR-γ）已被发现在细胞增殖中起着重要作用，但它是否参与施万细胞分化从未被研究过。我们在坐骨神经损伤中发现，PPAR-γ的表达主要在施万细胞中减少，而在分化的施万细胞中增加。此外，内源性配体 15 d-PGJ（2）激活的 PPAR-γ增加了 PPAR-γ水平和施万细胞分化的表达，而这种作用可能被其拮抗剂 GDW9662 所保护。这些结果表明，PPAR-γ可以促进施万细胞分化，在外周神经损伤和再生中起着重要作用。
