Atef M, Ramadan A, Afifi N A, Youssef S A
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Dtsch Tierarztl Wochenschr. 1990 Aug;97(8):324-7.
Cefotaxime was once administered in goats via intravenous, intramuscular and subcutaneous routes for determination of blood and urine concentration, kinetic behaviour and bioavailability. Following a single intravenous injection, the blood concentration-time curve indicated two compartments open model, with an elimination half-life value (t1/2 beta) of 22.38 +/- 0.41 minutes. Both intramuscular and subcutaneous routes showed lower values i.e. 38.64 and 69.58 minutes. The lower apparent volume of distribution of cefotaxime in goats than one liter/kg elucidated lower distribution in tissues than in blood. After intramuscular and subcutaneous injections peak plasma cefotaxime concentrations were 77.8 +/- 1.7 and 44.0 +/- 0.8 micrograms/ml at 29.6 and 40.4 minutes, respectively. The average bioavailability of cefotaxime given by intramuscular and subcutaneous injection was 1.08 and 1.25, respectively. The cefotaxime concentration remained in urine 24 hours longer after subcutaneous injection than after intramuscular administration.
曾通过静脉内、肌肉内和皮下途径给山羊注射头孢噻肟，以测定血液和尿液浓度、动力学行为及生物利用度。单次静脉注射后，血药浓度-时间曲线显示为二室开放模型，消除半衰期值（t1/2β）为22.38±0.41分钟。肌肉内和皮下途径的消除半衰期值较低，分别为38.64分钟和69.58分钟。山羊体内头孢噻肟的表观分布容积低于1升/千克，这说明其在组织中的分布低于在血液中的分布。肌肉内和皮下注射后，头孢噻肟的血药峰浓度分别在29.6分钟和40.4分钟时达到77.8±1.7微克/毫升和44.0±0.8微克/毫升。肌肉内和皮下注射头孢噻肟的平均生物利用度分别为1.08和1.25。皮下注射后，头孢噻肟在尿液中的浓度比肌肉内给药后在尿液中保留的时间长24小时。
