Parvizi Javad, Walinchus Lesley, Adeli Bahar
The Rothman Institute of Orthopaedics, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Int J Artif Organs. 2011 Sep;34(9):847-55. doi: 10.5301/ijao.5000054.
Periprosthetic joint infection (PJI) is a significant and costly challenge to the orthopedic community. The lack of a gold standard for diagnosis remains the biggest obstacle in the detection and subsequent treatment of PJI. Molecular markers in the serum and joint fluid aspirate hold immense promise to enhance the development of a firm diagnostic criterion. The primary goal is one marker with high sensitivity and specificity. Here, we review our current research efforts in the field of molecular markers: C-reactive protein, erythrocyte sedimentation rate, white blood cells, and leukocyte esterase. Each marker has been studied to determine its sensitivity, specificity, and positive and negative predictive values in diagnosing PJI.
人工关节周围感染（PJI）是骨科领域面临的一个重大且代价高昂的挑战。缺乏诊断金标准仍然是PJI检测及后续治疗的最大障碍。血清和关节液抽吸物中的分子标志物对于完善诊断标准具有巨大潜力。主要目标是找到一种具有高灵敏度和特异性的标志物。在此，我们综述了目前在分子标志物领域的研究成果：C反应蛋白、红细胞沉降率、白细胞和白细胞酯酶。对每种标志物进行了研究，以确定其在诊断PJI时的灵敏度、特异性以及阳性和阴性预测值。
