Reinmuth N, Heigener D, Reck M
Internistische Onkologie der Thoraxtumoren, Thoraxklinik am Universitätsklinikum Heidelberg, Amalienstrasse 5, Heidelberg, Germany.
Internist (Berl). 2011 Dec;52(12):1414-21. doi: 10.1007/s00108-011-2925-1.
Within recent years, the treatment of non-small cell lung cancer has become increasingly heterogeneous and complex. New cytotoxic agents and drugs against molecular targets have been developed. Moreover, new indications for therapy such as maintenance therapy have been explored. In addition, by assessing defined molecular markers, it is possible to identify patients who may likely respond to a given treatment. This approach will continue in the future; thus, it will be possible to characterize patient into subgroups based on molecular, histological, or clinical markers. This review will summarize the current state of the art in the treatment of non-small cell lung cancer.
近年来,非小细胞肺癌的治疗变得越来越多样化和复杂。新型细胞毒性药物和针对分子靶点的药物已被研发出来。此外,还探索了如维持治疗等新的治疗适应证。另外,通过评估特定的分子标志物,可以识别可能对特定治疗有反应的患者。这种方法在未来还会继续;因此,将有可能根据分子、组织学或临床标志物将患者分为不同亚组。本综述将总结非小细胞肺癌治疗的当前技术水平。