胺碘酮致多结节性甲状腺肿伴甲状腺乳头状癌甲状腺功能亢进症 1 例报告。
Amiodarone-induced thyrotoxicosis with thyroid papillary cancer in multinodular goiter: case report.
机构信息
Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan.
出版信息
Med Princ Pract. 2012;21(2):190-2. doi: 10.1159/000333697. Epub 2011 Nov 17.
OBJECTIVE
To report a case of amiodarone-induced thyrotoxicosis (AIT) concomitant with thyroid cancer in multinodular goiter (MNG).
CLINICAL PRESENTATION AND INTERVENTION
A 61-year-old man treated with amiodarone for 5 years presented with mild sweating. He was found to have AIT simultaneously with thyroid papillary cancer and MNG. Administration of amiodarone was stopped, and he was treated with methimazole for AIT. Five weeks after the initial treatment, thyroid function normalized. Total thyroidectomy was considered to enable use of amiodarone again.
CONCLUSION
This case showed that thyrotoxicosis, MNG and amiodarone may contribute to thyroid carcinogenesis. Amiodarone should be carefully commenced in cases with MNG.
目的
报告一例胺碘酮引起的多结节性甲状腺肿伴甲状腺癌的甲状腺功能亢进症（AIT）。
临床表现及干预
一名 61 岁男性，服用胺碘酮 5 年，出现轻度出汗。发现他同时患有甲状腺乳头状癌和多结节性甲状腺肿伴 AIT。停用胺碘酮，并用甲巯咪唑治疗 AIT。初始治疗 5 周后，甲状腺功能恢复正常。考虑行甲状腺全切除术，以便再次使用胺碘酮。
结论
本例表明，甲状腺功能亢进症、多结节性甲状腺肿和胺碘酮可能促进甲状腺癌的发生。在多结节性甲状腺肿的情况下，应谨慎开始使用胺碘酮。
Zotero 插件