细胞分化与癌变中的FACT - Suppr

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FACT in Cell Differentiation and Carcinogenesis.

作者信息

Hsieh Fu-Kai, Kulaeva Olga I, Orlovsky Igor V, Studitsky Vasily M

出版信息

Oncotarget. 2011 Nov;2(11):830-2. doi: 10.18632/oncotarget.356.

DOI:10.18632/oncotarget.356

PMID:22095465

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3259993/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/274d/3259993/0e0e2231c5b0/oncotarget-02-830-g001.jpg

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本文引用的文献

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells.FACT在哺乳动物组织中的表达表明其在维持细胞未分化状态中发挥作用。

Oncotarget. 2011 Oct;2(10):783-96. doi: 10.18632/oncotarget.340.

Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events.组蛋白伴侣 FACT 通过多个协同结合事件协调核小体相互作用。

J Biol Chem. 2011 Dec 2;286(48):41883-41892. doi: 10.1074/jbc.M111.301465. Epub 2011 Oct 3.

Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.Curaxins：通过靶向 FACT 同时抑制 NF-κB 并激活 p53 的抗癌化合物。

Sci Transl Med. 2011 Aug 10;3(95):95ra74. doi: 10.1126/scitranslmed.3002530.

Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.从抑制 FACT 组蛋白伴侣缺陷的组蛋白突变体中洞察核小体重组的机制。

Genetics. 2011 Aug;188(4):835-46. doi: 10.1534/genetics.111.128769. Epub 2011 May 30.

Mass spectrometric studies on epigenetic interaction networks in cell differentiation.基于质谱的细胞分化中表观遗传互作网络研究。

J Biol Chem. 2011 Apr 15;286(15):13657-68. doi: 10.1074/jbc.M110.204800. Epub 2011 Feb 18.

Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II.RNA聚合酶II通过过程中染色质重塑与恢复的机制。

Nat Struct Mol Biol. 2009 Dec;16(12):1272-8. doi: 10.1038/nsmb.1689. Epub 2009 Nov 22.

yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement.yFACT在不置换H2A - H2B的情况下诱导核小体DNA的全局可及性。

Mol Cell. 2009 Aug 14;35(3):365-76. doi: 10.1016/j.molcel.2009.06.024.

Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome.染色质和转录相关因子在整个酿酒酵母基因组的编码区域内抑制转录。

PLoS Biol. 2008 Nov 11;6(11):e277. doi: 10.1371/journal.pbio.0060277.

The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo.FACT复合物与延伸中的RNA聚合酶II一同移动，对体内转录起始的保真度很重要。

Mol Cell Biol. 2003 Nov;23(22):8323-33. doi: 10.1128/MCB.23.22.8323-8333.2003.

Transcription elongation factors repress transcription initiation from cryptic sites.转录延伸因子抑制来自隐蔽位点的转录起始。

Science. 2003 Aug 22;301(5636):1096-9. doi: 10.1126/science.1087374.

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