Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
J Magn Reson Imaging. 2012 Mar;35(3):717-22. doi: 10.1002/jmri.22893. Epub 2011 Nov 16.
To assess the effects of gadolinium-based contrast agent (GBCA) on (1) H-magnetic resonance spectroscopy (MRS) of the breast at 3.0-T.
Patients (n = 98) with breast cancer (98 lesions) underwent MRS (point-resolved spectroscopy sequence [PRESS]; TR/TE, 2000/100 msec; voxel size, 15 × 15 × 15 mm) before the administration of GBCA. In 52 of those patients, MRS was also performed after the administration of GBCA. The voxel-of-interest (VOI) was placed by referring to the noncontrast-enhanced MRI (diffusion-weighted images combined with fat-suppressed T2-weighted images). We reviewed and graded the appropriateness of VOI location compared to the correlating enhancement lesions. Integral values of the choline peak at a frequency of 3.2 ppm on MRS were compared before and after the administration of GBCA.
The VOI was placed correctly in 64 lesions (65%), although the VOI was placed outside the targeted lesion in 34 lesions (35%). The integral value of the choline peak on MRS decreased significantly after the administration of GBCA (P < 0.001).
Accumulation of GBCA in breast cancer could affect the choline peak on MRS. MRS of breast cancer at 3.0-T can be recommended to be acquired before contrast-enhanced study; however, some problems remain in VOI placement with reference to the noncontrast-enhanced study.
评估钆基对比剂（GBCA）对 3.0T 磁共振波谱（MRS）乳腺的影响。
98 例乳腺癌患者（98 个病灶）在注射 GBCA 前进行 MRS（点分辨波谱序列[PRESS]；TR/TE，2000/100ms；体素大小，15×15×15mm）。其中 52 例患者在注射 GBCA 后也进行了 MRS。感兴趣区（VOI）的位置是通过参考非增强 MRI（弥散加权图像结合脂肪抑制 T2 加权图像）来确定的。我们回顾并分级了 VOI 相对于相关增强病变的位置的适当性。比较 GBCA 给药前后 MRS 上 3.2ppm 处胆碱峰的积分值。
虽然在 34 个病灶（35%）中 VOI 位于目标病灶之外，但在 64 个病灶（65%）中正确放置了 VOI。MRS 上胆碱峰的积分值在 GBCA 给药后显著降低（P<0.001）。
GBCA 在乳腺癌中的积聚可能会影响 MRS 上的胆碱峰。建议在进行增强研究之前进行 3.0T 乳腺 MRS，但在参考非增强研究时，VOI 的定位仍存在一些问题。
