HIV感染对急性躁狂发作恢复时间的影响。
Effect of HIV infection on time to recovery from an acute manic episode.
作者信息
Nakimuli-Mpungu E, Mutamba B, Nshemerirwe S, Kiwuwa Ms, Musisi S
机构信息
Mental Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
出版信息
HIV AIDS (Auckl). 2010;2:185-9. doi: 10.2147/HIV.S9978. Epub 2010 Sep 29.
INTRODUCTION
Understanding factors affecting the time to recovery from acute mania is critical in the management of manic syndromes. The aim of this study was to determine the effect of HIV infection on time to recovery from acute mania.
METHODS
We performed a retrospective study in which medical charts of individuals who were treated for acute mania were reviewed. Survival analysis with Cox regression models were used to compare time to recovery from an acute manic episode between human immunodeficiency virus (HIV)-positive individuals and HIV-negative individuals.
RESULTS
Median survival time was one week for HIV-positive individuals and more than four weeks for HIV-negative individuals (χ(2) = 18.4, P value = 0.000). HIV infection was the only marginally significant independent predictor of survival probability on the acute admission ward (hazards ratio 2.87, P = 0.06).
CONCLUSION
Acute mania in HIV-infected persons responds faster to psychotropic drugs compared with that in HIV-negative persons.
引言
了解影响急性躁狂症恢复时间的因素对于躁狂综合征的管理至关重要。本研究的目的是确定艾滋病毒感染对急性躁狂症恢复时间的影响。
方法
我们进行了一项回顾性研究，对接受急性躁狂症治疗的个体的病历进行了审查。使用Cox回归模型进行生存分析，以比较人类免疫缺陷病毒（HIV）阳性个体和HIV阴性个体从急性躁狂发作中恢复的时间。
结果
HIV阳性个体的中位生存时间为1周，HIV阴性个体超过4周（χ(2)=18.4，P值=0.000）。HIV感染是急性入院病房生存概率的唯一边缘显著独立预测因素（风险比2.87，P=0.06）。
结论
与HIV阴性者相比，HIV感染者的急性躁狂症对精神药物的反应更快。
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