Baradari Afshin Gholipour, Emami Zeydi Amir, Espahbodi Fatemeh, Shahmohammadi Soheyla
Department of Anesthesiology and Critical Care, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Pak J Biol Sci. 2011 May 15;14(10):595-9.
Chronic inflammation, as reflected by increased level of acute phase protein such as C-reactive Protein (CRP) is highly prevalent in hemodialysis patients. CRP is a strong predictor of overall and cardiovascular mortality and morbidity in hemodialysis patients. This research was conducted to determine the C-reactive Protein (CRP) levels and its correlation to demographic and clinical characteristics and Laboratory values in hemodialysis patients in Sari, Iran. In a cross sectional study, 147 hemodialysis patients were studied. Patients' demographic and clinical data were recorded and also serum CRP, Cholesterol, Albumin, Phosphorous, Calcium, Hemoglobin and Hematocrit levels were measured. Overall, the mean CRP concentration was 15.8 mg L(-1). With considering to the different cutoff point (5, 6.2, 10 mg L(-1)) for CRP level, 107 patients (72.8%) had CRP level >5 mg L(-1), 99 patients (67.3%) had CRP level > 6.2 mg L(-1) and 77 patients (52.4%) had CRP level >10 nmg L(-1). The CRP levels greater than 6.2, had a direct statistically significant correlation with duration of hemodialysis and phosphorus level (p = 0.01). Also, CRP levels above 10 mg L(-1) had a direct statistically significant correlation with age and phosphorus levels (p = 0.02). According to the prevalence of high CRP level and it's correlation with age, duration ofhemodialysis and phosphorus level in hemodialysis patients, CRP level should be screened in this group of patients routinely because of its prognostic importance.
如急性期蛋白如C反应蛋白（CRP）水平升高所反映的，慢性炎症在血液透析患者中非常普遍。CRP是血液透析患者总体及心血管死亡率和发病率的有力预测指标。本研究旨在确定伊朗萨里血液透析患者的C反应蛋白（CRP）水平及其与人口统计学、临床特征和实验室值的相关性。在一项横断面研究中，对147例血液透析患者进行了研究。记录患者的人口统计学和临床数据，并测量血清CRP、胆固醇、白蛋白、磷、钙、血红蛋白和血细胞比容水平。总体而言，CRP平均浓度为15.8 mg L⁻¹。考虑到CRP水平的不同临界值（5、6.2、10 mg L⁻¹），107例患者（72.8%）的CRP水平>5 mg L⁻¹，99例患者（67.3%）的CRP水平>6.2 mg L⁻¹，77例患者（52.4%）的CRP水平>10 mg L⁻¹。CRP水平大于6.2与血液透析时间和磷水平呈直接的统计学显著相关性（p = 0.01）。此外，CRP水平高于10 mg L⁻¹与年龄和磷水平呈直接的统计学显著相关性（p = 0.02）。根据血液透析患者高CRP水平的患病率及其与年龄、血液透析时间和磷水平的相关性，鉴于其预后重要性，应常规筛查该组患者的CRP水平。
