Han Jiang-yu, Cui Jian-ping
Department of Chinese Medicine Teaching Research, Medical College of Huzhou Normal College, Zhejiang.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Oct;31(10):1346-8.
To assess the intervention of Biantong Huangqi Ointment (BHO) combined with Western medicine (WM) on the recurrence of bronchial asthma (BA).
Eighty-four BA children patients were randomly assigned to the treatment group (43 cases) and the control group (41 cases). During the period of onset, patients in the two groups were treated by WM alone. During the remission phase, patients in the treatment group took BHO, one dose daily, while those in the control group were treated with atomized inhalation of Budesonide and Salbutamol (0.5 mL each time for those 3 -8 years old; 0.75 mL each time for >or=those 8-12 years old). The therapeutic course for them all was 1 month. The serum levels of IgG and IgE before and after treatment, 6 and 12 months after withdrawal of medication were detected in the two groups, and the recurrence rate of BA observed in the two groups.
The recurrence rate of the treatment group was obviously lower than that of the control group after withdrawal of medication (9.5% vs 24.4% for 6 months, 14.0% vs 34.1% for 12 months), showing statistical difference between the two groups (P<0.05). The serum IgG level of children patients in the treatment group increased continuously after medication. The high serum IgE level state obtained long-term and effective relief.
BHO showed favorable anti-recurrent effect on children's BA. Its mechanism might be associated with regulating children's immune system.
评估变通黄芪膏（BHO）联合西药（WM）对支气管哮喘（BA）复发的干预作用。
84例BA患儿随机分为治疗组（43例）和对照组（41例）。发作期两组患儿均仅采用西药治疗。缓解期，治疗组患儿服用BHO，每日1剂，对照组患儿采用布地奈德和沙丁胺醇雾化吸入治疗（3 - 8岁患儿每次0.5 mL；≥8 - 12岁患儿每次0.75 mL）。两组疗程均为1个月。检测两组治疗前后、停药6个月及12个月后的血清IgG和IgE水平，并观察两组BA的复发率。
停药后治疗组的复发率明显低于对照组（6个月时为9.5%对24.4%，12个月时为14.0%对34.1%），两组比较差异有统计学意义（P<0.05）。治疗组患儿用药后血清IgG水平持续升高。高血清IgE水平状态得到长期有效缓解。
BHO对儿童BA有良好的抗复发作用。其机制可能与调节儿童免疫系统有关。
