转化生长因子e型对上皮细胞和成纤维细胞的促有丝分裂作用——与其他生长因子的比较。

Mitogenic effects of transforming growth factor type e on epithelial and fibroblastic cells--comparison with other growth factors.

作者信息

Brown C A, Halper J

机构信息

Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.

出版信息

Exp Cell Res. 1990 Oct;190(2):233-42. doi: 10.1016/0014-4827(90)90191-c.

DOI:10.1016/0014-4827(90)90191-c

PMID:2209726

Abstract

Transforming growth factor type-e (TGFe) is a novel TGF which was first described as a growth factor possibly involved in autocrine stimulation of anchorage-independent growth of carcinoma cells. Its later identification in normal tissues, plasma, and platelets suggested a role for TGFe in normal cell growth. This study shows that TGFe stimulates both anchorage-dependent and -independent growth of epithelial and fibroblastic cells of nonneoplastic origin. The mitogenic activity of TGFe in monolayer is slightly less than that of basic fibroblast growth factor, equipotent to that of epidermal growth factor, and greater than that of IGF-1. TGFe acts as a progression factor for both AKR-2B and Balb-3T3 cells. TGFe is also a potent mitogen for normal human epidermal keratinocytes and may therefore play a role in epidermal growth and regeneration.

摘要

转化生长因子e型（TGFe）是一种新型的转化生长因子，最初被描述为一种可能参与癌细胞非锚定依赖性生长自分泌刺激的生长因子。其后来在正常组织、血浆和血小板中的发现提示了TGFe在正常细胞生长中的作用。本研究表明，TGFe刺激非肿瘤来源的上皮细胞和成纤维细胞的锚定依赖性和非锚定依赖性生长。TGFe在单层培养中的促有丝分裂活性略低于碱性成纤维细胞生长因子，与表皮生长因子相当，且大于胰岛素样生长因子-1。TGFe对AKR-2B和Balb-3T3细胞均起促增殖因子的作用。TGFe也是正常人表皮角质形成细胞的有效促有丝分裂原，因此可能在表皮生长和再生中发挥作用。