Li Zhi Jie, Yang Qian Qian, Zhou You Lang
Hand Surgery Research Center, Research Central of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
Stem Cells Int. 2023 Jan 9;2023:4387630. doi: 10.1155/2023/4387630. eCollection 2023.
Tendons are an important part of the musculoskeletal system. Connecting muscles to bones, tendons convert force into movement. Tendon injury can be acute or chronic. Noticeably, tendon healing requires a long time span and includes inflammation, proliferation, and remodeling processes. The mismatch between endogenous and exogenous healing may lead to adhesion causing further negative effects. Management of tendon injuries and complications such as subsequent adhesion formation are still challenges for clinicians. Due to numerous factors, tendon healing is a complex process. This review introduces the role of various biological and mechanical factors and epigenetic regulation processes involved in tendon healing.
肌腱是肌肉骨骼系统的重要组成部分。肌腱将肌肉与骨骼相连，将力量转化为运动。肌腱损伤可分为急性和慢性。值得注意的是，肌腱愈合需要很长时间，包括炎症、增殖和重塑过程。内源性和外源性愈合之间的不匹配可能导致粘连，从而产生进一步的负面影响。肌腱损伤及后续粘连形成等并发症的处理仍是临床医生面临的挑战。由于多种因素，肌腱愈合是一个复杂的过程。本文综述了各种生物学和力学因素以及参与肌腱愈合的表观遗传调控过程的作用。
