[胶质瘤患者中MGMT表达水平的临床研究]
[The clinical research of the MGMT expression levels in glioma pations].
作者信息
Xia Hai-cheng, Zhu Zheng-quan, Liu Liang, Tian Hai-long, Sun Zhe
机构信息
Department of Neurosurgery Tumor Hospital Affiliated Xinjiang Medical University, Urumqi, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):265-7.
OBJECTIVE
To investigate the correlation between the expression of tumor O (6)-methylquanine DNA methyl-tranferase(MGMT) and pathological grade,and the influence of racial factors on tumor MGMT expression levels for glioma patients.
METHODS
Compare and analysis the correlation between the pathological grade and MGMT levels and the racial factors on MGMT expression levels by the immunohistochemical staining on the tumor specimens of 33 Uygur and 61 Han.
RESULTS
The positive rate of 61 Han gliomas pations with MGMT is 45.90% and 33 cases of the Uygur is 30.30% , there's no clear correlation between the racial factors and the tumor MGMT levels. (P >0.05). Comparative the 94 patients with pathological level and tumor MGMT level, there is no clear correlation between pathologic level and MGMT pression in tumor tissues (P >0.05).
CONCLUSION
There's no clear correlation of tumor MGMT expression and pathological levels; and there's no significant effect between racial factors and expression of glioma MGMT.
目的
探讨胶质瘤患者肿瘤O（6）-甲基鸟嘌呤-DNA甲基转移酶（MGMT）表达与病理分级之间的相关性，以及种族因素对肿瘤MGMT表达水平的影响。
方法
对33例维吾尔族和61例汉族患者的肿瘤标本进行免疫组化染色，比较分析病理分级与MGMT水平之间的相关性以及种族因素对MGMT表达水平的影响。
结果
61例汉族胶质瘤患者MGMT阳性率为45.90%，33例维吾尔族患者为30.30%，种族因素与肿瘤MGMT水平之间无明显相关性（P>0.05）。比较94例患者的病理分级与肿瘤MGMT水平，肿瘤组织中病理分级与MGMT表达之间无明显相关性（P>0.05）。
结论
肿瘤MGMT表达与病理分级无明显相关性；种族因素与胶质瘤MGMT表达之间无显著影响。
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