[血清高尔基体蛋白73（GP73）、甲胎蛋白（AFP）及凝集素反应性甲胎蛋白（AFP-L3）表达在原发性肝癌中的意义]
[Significance of serum golgi protein 73 (GP73), alpha-fetoprotein (AFP) and lectin-reactive alpha-fetoprotein (AFP-L3) expresssion in primary hepatic carcinoma].
作者信息
Xu Wen-fang, Fei Ying-ming, Zhou Jian-kang, Shen Hua-jing, Chen Xue-fang, Lv Qiu-qiong, Ding Yu-yun
机构信息
Shaoxing Sixth People's Hospital, Zhejiang, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):286-8.
OBJECTIVE
To explore the alone and joint diagnostic value of serum golgi protein 73 (GP73), alpha-fetoprotein (AFP) and the percentage of lectin-reactive aipha-fetoprotein (AFP-L3) of primary hepatic carcinoma (PHC), and provide a novel method for diagnosis for PHC and screening for high-risk population.
METHODS
ELISA was used to detect the serum level of GP73, AFP and AFP-L3% in 81 cases of PHC,176 cases chronic hepatitis and liver cirrhosis, 30 cases other tumber cancer and 40 cases of health people.
RESULTS
The sensitivity of GP73, AFP and AFP-L3% in PHC is 77.78%, 62.69% and 51.85%, and the specificity is 84.55%, 86.99% and 96.34%, respectively. Joint detection could increase the sensitivity up to 88.89%.
CONCLUSION
GP73 was a high sensitivity mark for dignosis of PHC, while AFP-L3% was a high specificity mark for dignosis of PHC. The joint detection could improve PHC diagnostic performance.
目的
探讨血清高尔基体蛋白73（GP73）、甲胎蛋白（AFP）及凝集素反应性甲胎蛋白百分比（AFP-L3）对原发性肝癌（PHC）的单独及联合诊断价值，为PHC的诊断及高危人群筛查提供新方法。
方法
采用酶联免疫吸附测定法（ELISA）检测81例PHC患者、176例慢性肝炎和肝硬化患者、30例其他肿瘤患者及40例健康人的血清GP73、AFP及AFP-L3%水平。
结果
GP73、AFP及AFP-L3%对PHC诊断的敏感性分别为77.78%、62.69%和51.85%，特异性分别为84.55%、86.99%和96.34%。联合检测可使敏感性提高至88.89%。
结论
GP73是PHC诊断的高敏感性标志物，而AFP-L3%是PHC诊断的高特异性标志物。联合检测可提高PHC的诊断效能。
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