Cao Hong, Zhang Ka, Shu Xin, Xu Qi-huan, Li Gang
Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):304-6.
To study the status of detection of hepatitis C core antigen in intravenous drug addictions, and discuss the foreground of the hepatitis C core antigen ELISA test system.
HCV core antigen, HCV RNA quantity, anti HCV-IgG, HBsAg were analysis in all the plasma samples taken from 93 cases of intravenous drug users.
The specialty and sensitivity of HCV core antigen in intravenous drug addictions 100% -54% separately. When HBsAg were positive, the sensitivity of HCV core antigen was 38%, while HBsAg negative, the sensitivity of HCV core antigen was 69% (P < 0.01).
The detections of HCV core antigen showed high specialty but low sensitivity in intravenous drug addictions. The positive rate has positive relation with HCV RNA virus logarithm quantity. Coinfection with HBV are the interfere factor of HCV core antigen detection. In screening experimentations, the detection of HCV core antigen in plasma may be applied as supplement method for anti-HCV-IgG. It can also be used to monitor viremia in HCV infection.
研究丙型肝炎核心抗原在静脉吸毒人群中的检测状况，并探讨丙型肝炎核心抗原酶联免疫吸附试验检测系统的应用前景。
对93例静脉吸毒者血浆标本进行丙型肝炎核心抗原、丙型肝炎病毒核糖核酸定量、抗丙型肝炎病毒免疫球蛋白G及乙型肝炎表面抗原检测分析。
丙型肝炎核心抗原在静脉吸毒人群中的特异性和敏感性分别为100%和54%。当乙型肝炎表面抗原阳性时，丙型肝炎核心抗原的敏感性为38%；乙型肝炎表面抗原阴性时，丙型肝炎核心抗原的敏感性为69%（P<0.01）。
丙型肝炎核心抗原检测在静脉吸毒人群中特异性高但敏感性低，阳性率与丙型肝炎病毒核糖核酸病毒载量对数呈正相关，合并乙型肝炎病毒感染是丙型肝炎核心抗原检测的干扰因素。在筛查试验中，血浆中丙型肝炎核心抗原检测可作为抗丙型肝炎病毒免疫球蛋白G检测的补充方法，也可用于丙型肝炎病毒感染的病毒血症监测。
