HIV 杀微生物剂研发进展。
Advances in HIV microbicide development.
机构信息
Department of Microbiology & Immunology, University of Rochester, Rochester, NY 14627, USA.
出版信息
Future Med Chem. 2011 Dec;3(16):2101-16. doi: 10.4155/fmc.11.153.
Abstract
There is an urgent need control the spread of the global HIV pandemic. A microbicide, or topical drug applied to the mucosal environment to block transmission, is a promising HIV prevention strategy. The development of a safe and efficacious microbicide requires a thorough understanding of the mucosal environment and its role in HIV transmission. Knowledge of the key events in viral infection identifies points at which the virus might be most effectively targeted by a microbicide. The cervicovaginal and rectal mucosa play an important role in the innate defense against HIV, and microbicides must not interfere with these functions. In this review, we discuss the current research on HIV microbicide development.
摘要
目前迫切需要控制全球 HIV 疫情的蔓延。杀微生物剂，即局部应用于黏膜环境以阻断传播的药物，是一种很有前途的 HIV 预防策略。安全有效的杀微生物剂的开发需要对黏膜环境及其在 HIV 传播中的作用有透彻的了解。对病毒感染关键事件的认识可以确定病毒最有可能被杀微生物剂靶向的部位。宫颈阴道和直肠黏膜在先天防御 HIV 方面发挥着重要作用，杀微生物剂不能干扰这些功能。在这篇综述中，我们讨论了 HIV 杀微生物剂开发的当前研究。
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