Deng Hong Kuan, Le Rhun Danielle, Lecuelle Benoit, Le Naour Evelyne, Vayssier-Taussat Muriel
USC INRA Bartonella et tiques, Anses, Maisons-Alfort, France.
FEMS Immunol Med Microbiol. 2012 Feb;64(1):143-5. doi: 10.1111/j.1574-695X.2011.00908.x.
Bartonella spp. are intra-erythrocytic pathogens of mammals. In this study, we investigated the role of the spleen, and other tissue and organs in Bartonella infection. Using an in vivo model of mice infection by Bartonella birtlesii, we detected accumulation of bacteria in the spleen, with transient infection of the liver, but failed to detect any bacteria in brain or lymph nodes. We then compared bacteraemia in normal Balb/C mice and in splenectomized mice. Bacteraemia in splenectomized mice was 10-fold higher than in normal mice and lasted 2 weeks longer. In conclusion, the spleen seems to retain and filter infected erythrocytes rather than to be a sanctuary for chronic Bartonella infection.
巴尔通体属是哺乳动物的红细胞内病原体。在本研究中，我们调查了脾脏以及其他组织和器官在巴尔通体感染中的作用。利用伯氏巴尔通体感染小鼠的体内模型，我们检测到细菌在脾脏中积聚，肝脏有短暂感染，但在脑或淋巴结中未检测到任何细菌。然后我们比较了正常Balb/C小鼠和脾切除小鼠的菌血症情况。脾切除小鼠的菌血症比正常小鼠高10倍，且持续时间长2周。总之，脾脏似乎能滞留并过滤受感染的红细胞，而不是慢性巴尔通体感染的庇护所。
