Translational Oncogenomic Unit, Italian National Cancer Institute Regina Elena, Rome 00144, Italy.
Mol Cell. 2011 Nov 18;44(4):515-6. doi: 10.1016/j.molcel.2011.11.003.
In this issue of Molecular Cell, Sen et al. (2011) report the involvement of PGC1α in modulating the transcriptional activity of p53 in metabolically challenged cells. They provide important insights into the mechanisms linking length and strength of the metabolic stress stimuli to the specific activation of p53 target genes.
在本期《分子细胞》中，Sen 等人（2011）报道了 PGC1α 在调节代谢应激细胞中 p53 的转录活性方面的作用。他们为将代谢应激刺激的长度和强度与 p53 靶基因的特异性激活联系起来的机制提供了重要的见解。
