Renard E, De Boisvilliers F, Monnier L, Orsetti A
Clinique des Maladies Métaboliques et Endocriniennes, Hôpital Lapeyronie, Montpellier.
Diabete Metab. 1990 May-Jun;16(3):260-3.
Disclosure of microalbuminuria gives a hope to improve renal and perhaps cardiovascular outcome of diabetes mellitus by the mean of an early treatment. We studied in 30 diabetic patients for each sex, consecutively admitted to hospital the efficacy of a colorimetric tablet-test for quick screening of microalbuminuria. The results obtained from a 24 hours-urine collection are compared to those observed with a reference radio-immunologic method. In this population whose prevalence for microalbuminuria over 15 micrograms/mn is 30%, the test shows a sensibility and a negative predictive value of 100%, but a specificity and a positive predictive value of about 40%. Else, intensity of positivity follows systolic blood pressure and creatininemia increase. If the good and cheap screening value of the test can be acknowledged, its positivity needs however a precise evaluation by a reference assay before therapeutic decision.
微量白蛋白尿的发现为通过早期治疗改善糖尿病患者的肾脏以及可能的心血管结局带来了希望。我们对连续入院的30名男性和30名女性糖尿病患者进行了研究，以评估一种比色片剂检测法快速筛查微量白蛋白尿的效果。将24小时尿液收集的结果与参考放射免疫法观察到的结果进行比较。在该人群中，微量白蛋白尿超过15微克/分钟的患病率为30%，该检测显示敏感性和阴性预测值为100%，但特异性和阳性预测值约为40%。此外，阳性强度随收缩压和肌酐血症升高而增加。如果该检测良好且廉价的筛查价值得到认可，然而在做出治疗决策之前，其阳性结果需要通过参考检测进行精确评估。
