San Diego State University, Department of Psychology, San Diego, CA 92120, USA.
Int J Psychophysiol. 2012 Mar;83(3):276-81. doi: 10.1016/j.ijpsycho.2011.11.001. Epub 2011 Nov 18.
The largest genetic susceptibility factor for Alzheimer's disease is the Apolipoprotein E (ApoE) ε4 allele. Cognitive decline and olfactory impairment are greater in those positive for the ε4 allele. This study sought to determine if the olfactory event-related potential (OERP), compared to the visual ERP, would be sensitive to these subtle declines. Participants included 40 individuals from two age groups, half of each group were ε4 allele positive and half were ε4 negative. Visual ERPs did not demonstrate significant differences between ApoE groups. OERPs demonstrated robust age by ApoE interactions. P3 latencies were significantly longer in ε4 young and middle age participants. These findings suggest that very early olfactory and cognitive changes related to ApoE status are detectible via the OERP.
阿尔茨海默病最大的遗传易感性因素是载脂蛋白 E（ApoE）ε4 等位基因。携带 ε4 等位基因的个体认知能力下降和嗅觉障碍更为严重。本研究旨在确定嗅觉事件相关电位（OERP）与视觉 ERP 相比，是否对这些细微下降更为敏感。参与者包括来自两个年龄组的 40 个人，每个年龄组的一半是 ε4 等位基因阳性，另一半是 ε4 等位基因阴性。视觉 ERP 在 ApoE 组之间没有显示出显著差异。OERP 显示出年龄与 ApoE 相互作用的强大关系。P3 潜伏期在 ε4 年轻和中年参与者中显著延长。这些发现表明，与 ApoE 状态相关的非常早期的嗅觉和认知变化可以通过 OERP 检测到。
