通过改善氧化应激和促炎细胞因子发挥肾保护作用的琴叶珊瑚。
Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines.
机构信息
Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan, China.
出版信息
J Ethnopharmacol. 2012 Jan 6;139(1):207-13. doi: 10.1016/j.jep.2011.11.002. Epub 2011 Nov 10.
ETHNOPHARMACOLOGICAL RELEVANCE
Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness.
AIM OF THE STUDY
The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT).
MATERIALS AND METHODS
The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice.
RESULTS
In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway.
CONCLUSIONS
It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome.
民族药理学相关性
大血藤在传统的中医中被用于治疗因肾脏/膀胱问题而导致的水肿患者，因为其具有令人满意的治疗效果。
研究目的
本研究旨在研究大血藤总多酚部分（PMT）的肾脏保护特性。
材料和方法
评估血浆和肾脏组织的生化标准，以研究 PMT 对高脂血症小鼠嘌呤霉素氨基核苷诱导的慢性肾病综合征（NS）的影响。
结果
在这项研究中，经过 9 周的 PMT 治疗后，NS 和高血脂得到了改善。此外，PMT 能够调节肾脏氧化应激和血管内皮生长因子-一氧化氮（VEGF-NO）通路的水平。
结论
这代表了 PMT 作为一种治疗代谢综合征相关 NS 的潜在资源。
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