Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, United States.
Behav Brain Res. 2012 Feb 1;227(1):300-4. doi: 10.1016/j.bbr.2011.11.010. Epub 2011 Nov 15.
Exposure to repeated stress can lead to diverse and widespread behavioral consequences, including reduction in food and water intake and subsequent diminution in weight gain. Many reports have suggested that repeated stress substantially alters the neurochemistry, morphology and physiology of neurons within the bed nucleus of the stria terminalis (BNST). Here we investigate the role of the BNST in mediating the reduced weight gain observed during repeated stress. Rats exposed to a one-week variate stress paradigm exhibited a reduction in weight gain over the course of the 7-day paradigm. Excitotoxic lesions to a subregion of the anterolateral BNST containing the oval nucleus had no effects early in the 7-day paradigm, but significantly attenuated the effects of repeated stress on weight gain by the last day of stress. These data suggest that at least two mechanisms mediate the effects of stress on body weight gain, and that when stressor exposure becomes repeated, the BNST is recruited, worsening the symptoms of stressor exposure.
反复的压力暴露会导致多种广泛的行为后果，包括食物和水摄入量的减少以及随后体重增加的减少。许多报告表明，反复的压力会极大地改变终纹床核（BNST）内神经元的神经化学、形态和生理学。在这里，我们研究 BNST 在介导反复压力下观察到的体重增加减少中的作用。暴露于一周多变应激范式的大鼠在 7 天范式过程中表现出体重增加减少。在前外侧 BNST 的包含卵圆核的亚区的兴奋性毒性损伤在 7 天范式的早期没有影响，但在应激的最后一天显著减弱了重复应激对体重增加的影响。这些数据表明，至少有两种机制介导了压力对体重增加的影响，并且当应激暴露变得重复时，BNST 被招募，加重了应激暴露的症状。
