使用优质囊胚培养液上清（SEHB）刺激子宫内膜可改善接受卵胞浆内单精子注射（ICSI）的夫妇的妊娠结局：一项随机临床试验。
Stimulation of the endometrium with high-grade blastocyst culture supernatant (SEHB) can improve pregnancy outcome for couples undergoing intracytoplasmic sperm injection (ICSI): a randomized clinical trial.
机构信息
Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
出版信息
Arch Gynecol Obstet. 2012 Apr;285(4):1167-71. doi: 10.1007/s00404-011-2143-z. Epub 2011 Nov 20.
PURPOSE
To evaluate the impact of stimulating the endometrium with high-grade blastocyst culture supernatant (SEHB) perfusion before blastocyst transfer (BT) on implantation rate, pregnancy rate, and pregnancy outcome in ICSI cycles.
MATERIALS AND METHODS
Ninety-four infertile couples who were referred to the Valiasr department of Imam Hospital complex between January 2010 and March 2011 enrolled in this randomized clinical trial. They were randomly divided into only BT or SEHB groups. Implantation rates, pregnancy rates, abortion, preterm and term delivery rates were compared between the two groups.
RESULTS
Implantation rates and pregnancy rates did not differ significantly between the two groups. The abortion rate was significantly higher in the BT only group while term delivery was significantly higher in SEHB group. Odds ratios of term delivery and abortion were 4.5 (p = 0.001) and 0.3 (p = 0.04), respectively.
CONCLUSION
The SEHB application may improve pregnancy outcome in infertile couples who are candidates for the ICSI reproductive method.
目的
评估在胚胎移植（BT）前使用高等级囊胚培养上清液（SEHB）刺激子宫内膜对 ICSI 周期中着床率、妊娠率和妊娠结局的影响。
材料与方法
2010 年 1 月至 2011 年 3 月期间，共有 94 对不孕夫妇在伊朗马什哈德的瓦利阿斯尔医院就诊，参与了这项随机临床试验。他们被随机分为仅 BT 组或 SEHB 组。比较两组之间的着床率、妊娠率、流产率、早产率和足月产率。
结果
两组之间的着床率和妊娠率无显著差异。仅 BT 组的流产率显著较高，而 SEHB 组的足月产率显著较高。足月产和流产的优势比分别为 4.5（p=0.001）和 0.3（p=0.04）。
结论
对于接受 ICSI 生殖方法的不孕夫妇，SEHB 的应用可能会改善妊娠结局。
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