Motykova Eva, Zlatohlavek Lukáš, Prusikova Martina, Lanska Vera, Ceska Richard, Vasickova Ludmila, Vrablik Michal
Third Department of Internal Medicine, General University Hospital and 1st Medical Faculty of Charles University in Prague, Czech Republic.
Neuro Endocrinol Lett. 2011;32 Suppl 2:55-9.
Obesity is associated with increased inflammation which represents a link to atherosclerosis and cardiovascular disease. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an independent marker of inflammation and atherosclerosis risk. To assess the impact of weight loss on metabolic markers of atherosclerosis including Lp-PLA2 we examined a group of Czech non-diabetic obese/overweight children exposed to a lifestyle intervention.
Fourty unrelated overweight/obese non-diabetic Czech children (13.7 ± 2.1 years, average BMI at baseline 29.8 ± 2.6 kg/m2) underwent 4 weeks of lifestyle modification (reduction of energy intake to age matched optimum and supervised physical activity). Anthropometrical and biochemical variables were determined at baseline and after the intervention. Lp-PLA2 mass concentration was assessed using the ELISA kit. Wilcocson's rank test and Spearman's correlation were used for statistical analysis.
A significant decrease of BMI and waist circumference was associated with significant changes of plasma lipoprotein and glycaemia levels. Mass concentration of Lp-PLA2 at the baseline was 402 ± 94 μg/ml, after the intervention 368 ± 105 μg/ml (p=0.008). Change in Lp-PLA2 was associated with triglyceride level decrease (p=0.009).
Intensive lifestyle modification leading to body weight decrease results in significant changes of plasma lipoprotein levels and, also, a drop of Lp-PLA2 levels in paediatric obese patients. However, even after the intervention Lp-PLA2 concentrations in this patient group remain elevated suggesting possible increased atherosclerosis risk in later life.
肥胖与炎症增加相关，炎症是动脉粥样硬化和心血管疾病的一个关联因素。脂蛋白相关磷脂酶A2（Lp-PLA2）是炎症和动脉粥样硬化风险的独立标志物。为了评估体重减轻对包括Lp-PLA2在内的动脉粥样硬化代谢标志物的影响，我们对一组接受生活方式干预的捷克非糖尿病肥胖/超重儿童进行了研究。
40名无亲属关系的超重/肥胖非糖尿病捷克儿童（13.7±2.1岁，基线时平均BMI为29.8±2.6kg/m²）接受了4周的生活方式改变（将能量摄入减少至与年龄匹配的最佳水平，并进行有监督的体育活动）。在基线和干预后测定人体测量和生化变量。使用ELISA试剂盒评估Lp-PLA2质量浓度。采用Wilcocson秩和检验和Spearman相关性分析进行统计分析。
BMI和腰围的显著降低与血浆脂蛋白和血糖水平的显著变化相关。Lp-PLA2的质量浓度在基线时为402±94μg/ml，干预后为368±105μg/ml（p=0.008）。Lp-PLA2的变化与甘油三酯水平降低相关（p=0.009）。
导致体重减轻的强化生活方式改变会使小儿肥胖患者的血浆脂蛋白水平发生显著变化，同时Lp-PLA2水平也会下降。然而，即使在干预后，该患者组的Lp-PLA2浓度仍升高表明其晚年动脉粥样硬化风险可能增加。
