Marks Rebecca A, Cramer Harvey M, Wu Howard H
IU Health Pathology Laboratory, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202,
Diagn Cytopathol. 2013 Jan;41(1):81-4. doi: 10.1002/dc.21853. Epub 2011 Nov 18.
The cytopathologic diagnosis of basaloid squamous cell carcinoma can be problematic as there are several components of the differential diagnosis that share common cytomorphologic features. In this study, we report the fine-needle aspiration (FNA) findings of 16 basaloid squamous cell carcinoma cases and compare those cases to 16 cases of small cell carcinoma. To our knowledge, this is the largest series of basaloid squamous cell carcinoma FNA cases ever reported. The following cytomorphologic features were compared for both tumors: cohesive tissue fragments, single cells, adenoid cystic-like features (cribriform pseudoglandular lumina with hyaline materials), necrosis, nuclear size, nuclear molding, nucleoli, cytoplasm, and the presence of single keratinized cells. Adenoid cystic-like features and the presence of single keratinized cells were specific for basaloid squamous cell carcinoma (P < 0.05).
基底样鳞状细胞癌的细胞病理学诊断可能存在问题，因为鉴别诊断的几个组成部分具有共同的细胞形态学特征。在本研究中，我们报告了16例基底样鳞状细胞癌的细针穿刺抽吸（FNA）结果，并将这些病例与16例小细胞癌病例进行比较。据我们所知，这是迄今为止报道的最大系列的基底样鳞状细胞癌FNA病例。对两种肿瘤的以下细胞形态学特征进行了比较：黏附性组织碎片、单个细胞、腺样囊性样特征（伴有透明物质的筛状假腺腔）、坏死、核大小、核塑形、核仁、细胞质以及单个角化细胞的存在。腺样囊性样特征和单个角化细胞的存在对基底样鳞状细胞癌具有特异性（P < 0.05）。
