MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
J Infect Dis. 2012 Jan 15;205(2):289-96. doi: 10.1093/infdis/jir733. Epub 2011 Nov 18.
The importance of Mycoplasma genitalium in human immunodeficiency virus (HIV)-burdened sub-Saharan Africa is relatively unknown. We assessed the prevalence and explored determinants of this emerging sexually transmitted infection (STI) in high-risk women in Uganda.
Endocervical swabs from 1025 female sex workers in Kampala were tested for Mycoplasma genitalium using a commercial Real-TM polymerase chain reaction assay. Factors associated with prevalent Mycoplasma genitalium, including sociodemographics, reproductive history, risk behavior, and HIV and other STIs, were examined using multivariable logistic regression.
The prevalence of Mycoplasma genitalium was 14% and higher in HIV-positive women than in HIV-negative women (adjusted odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12-2.41). Mycoplasma genitalium infection was less prevalent in older women (adjusted OR, 0.61; 95% CI, .41-.90 for women ages 25-34 years vs <25 years; adjusted OR, 0.32; 95% CI, .15-.71 for women ≥ 35 years vs those <25 years) and in those who had been pregnant but never had a live birth (adjusted OR, 2.25; 95% CI, 1.04-4.88). Mycoplasma genitalium was associated with Neisseria gonorrhoeae (adjusted OR, 1.84; 95% CI, 1.13-2.98) and with Candida infection (adjusted OR, 0.41; 95% CI, .18-.91), and there was some evidence of association with Trichomonas vaginalis (adjusted OR, 1.56; 95% CI, 1.00-2.44).
The relatively high prevalence of Mycoplasma genitalium and its association with prevalent HIV urgently calls for further research to explore the potential role this emerging STI plays in the acquisition and transmission of HIV infection.
在受人类免疫缺陷病毒（HIV）影响的撒哈拉以南非洲地区，生殖支原体的重要性尚不清楚。我们评估了这种新出现的性传播感染（STI）在乌干达高危女性中的流行率，并探讨了其决定因素。
从坎帕拉的 1025 名女性性工作者的宫颈拭子中使用商业 Real-TM 聚合酶链反应检测生殖支原体。使用多变量逻辑回归分析与普遍存在的生殖支原体相关的因素，包括社会人口统计学、生殖史、风险行为以及 HIV 和其他 STI。
生殖支原体的流行率为 14%，在 HIV 阳性女性中高于 HIV 阴性女性（调整后的优势比[OR]，1.64；95%置信区间[CI]，1.12-2.41）。生殖支原体感染在年龄较大的女性中较为少见（调整后的 OR，0.61；95%CI，25-34 岁的女性为 0.41-0.90；≥35 岁的女性为 0.32-0.71；25 岁以下的女性），以及曾经怀孕但从未活产的女性（调整后的 OR，2.25；95%CI，1.04-4.88）。生殖支原体与淋病奈瑟菌（调整后的 OR，1.84；95%CI，1.13-2.98）和假丝酵母菌感染（调整后的 OR，0.41；95%CI，0.18-0.91）相关，并且与阴道毛滴虫感染有一定的关联（调整后的 OR，1.56；95%CI，1.00-2.44）。
生殖支原体的相对高流行率及其与普遍存在的 HIV 的关联迫切需要进一步研究，以探索这种新出现的 STI 在获得和传播 HIV 感染中的潜在作用。
