Sreelakshmi C, Datta K K R, Yadav J S, Reddy B V Subba
Division of Organic Chemistry-1, Indian Institute of Chemical Technology, Hyderabad 500007, India.
J Nanosci Nanotechnol. 2011 Aug;11(8):6995-7000. doi: 10.1166/jnn.2011.4240.
Biomolecules hosting the synthesis of nanoparticles has achieved considerable attention in recent decades due to their abundant availability, excellent biocompatibility and low toxicity. The present study demonstrates a rapid, cost-effective and eco-friendly fabrication of gold and silver nanoparticles at room temperature using natural honey as a source of stabilizing and reducing agent. The nanoparticles obtained were unambiguously characterized by using various characterization techniques such as transmission electron microscopy (TEM), UV-Visible absorption spectroscopy, X-ray diffraction and energy dispersive (EDX) X-ray analysis. The average size of Au and Ag nanoparticles are 10 and 12 nm respectively. Ag nanoparticles capped by honey exhibited superior antimicrobial activity while Au nanoparticles revealed passable activity against pathogenic bacteria and Candida albicans, including multi-resistant strains for the first time.
近几十年来，由于生物分子来源丰富、具有出色的生物相容性和低毒性，因此在纳米颗粒合成中使用生物分子受到了广泛关注。本研究展示了一种在室温下以天然蜂蜜作为稳定剂和还原剂，快速、经济高效且环保地制备金和银纳米颗粒的方法。通过使用透射电子显微镜（TEM）、紫外可见吸收光谱、X射线衍射和能量色散（EDX）X射线分析等各种表征技术，对所获得的纳米颗粒进行了明确的表征。金纳米颗粒和银纳米颗粒的平均尺寸分别为10纳米和12纳米。蜂蜜包覆的银纳米颗粒表现出卓越的抗菌活性，而金纳米颗粒首次显示出对包括多重耐药菌株在内的致病细菌和白色念珠菌具有尚可的活性。
