Department of Medical Pharmacology and CNR Institute of Neuroscience, University of Milan, Milano, Italy.
Eur J Neurosci. 2011 Nov;34(10):1655-62. doi: 10.1111/j.1460-9568.2011.07897.x.
Actin-capping and anti-capping proteins are crucial regulators of actin dynamics. Recent studies have indicated that these proteins may be heavily involved in all stages of synaptogenesis, from the emergence of filopodia, through neuritogenesis and synaptic contact stabilization, to the structural changes occurring at the synapse during potentiation phenomena. In this review, we focus on recent evidence pointing to an active role of actin-capping and anti-capping proteins in orchestrating the processes controlling neuronal connectivity and plasticity.
肌动蛋白加帽蛋白和抗加帽蛋白是肌动蛋白动力学的关键调节因子。最近的研究表明，这些蛋白质可能大量参与突触发生的所有阶段，从突刺的出现，通过神经突生成和突触接触稳定，到在增强现象期间发生的突触的结构变化。在这篇综述中，我们重点介绍了最近的证据，这些证据表明肌动蛋白加帽蛋白和抗加帽蛋白在协调控制神经元连接和可塑性的过程中发挥积极作用。
